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MYVIRALBOX > Funny Stories > Mysterious giant neurons, laughter neuroscience and potential LSD / Geektimes
Funny Stories

Mysterious giant neurons, laughter neuroscience and potential LSD / Geektimes

MVB Staff
Last updated: April 25, 2024 1:24 pm
MVB Staff
Published: April 16, 2017
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7 Min Read
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LSD

Let’s start with the news from all the beloved field of psychedelic research. Scientists believe that they could decipher the secret of the power of LSD. This substance can change your consciousness for a period of up to 18 hours, unlike, for example, from DMT (dimethyltryptamine), another powerful psychedelic substance that can turn off the brain for only 15 minutes. To understand the background, the researchers decided to disassemble the behavior of LSD at the molecular level. First they waited for the LSD molecule to connect to the serotonin receptor in the brain, and then they froze it in the form of a crystal. After that they built a three-dimensional image of the structure with the help of X-rays. It was there that they saw something unusual: typical drugs (and other molecules) arrive and leave the receptors in much the same way as cars call in and leave the garage. However, when the LSD was connected to the receptor, it covered itself with one part as if it were a lid. This lid held the molecule inside the receptor, so that it could work on psychedelic sensations without interruption. Protein proteins are constantly fidgeting around it, so in the end, this lid opens and releases the molecule. When scientists created a mutated receptor with a lid that opened much easier, they saw how LSD connected and disconnected much faster, and such a short-term connection caused other signal changes in the neuron. Psychedelics have promising potential for the treatment of anxiety, depression and addictions, so unraveling the method of action of LSD can help us to correct them so as to get all the positive effects, and not to send people to the sky with diamonds, and also to develop improved medications and correct existing ones.

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The LSD molecule connected to the receptor. The orange stick in the center is the “cover” holding it

To other news. Scientists recently discovered something unusual in the brain. As if ivy, wrapped around a tree, the brain of a mouse hugged a giant neuron. It connected with virtually all areas in both hemispheres, and resembled an electrical grid that feeds the city with electricity. Moreover, two more giant neurons that actively branched out in the brain, originated in the same area as the first.

They started from a site called “fence”, or “claustrum” – a thin sheet of cells , And one of the sites that have the most connections in the brain. It helps us use such cognitive functions as long-term planning. It has already been shown that claustrum is somehow connected with consciousness (stimulation by its electricity led to a sharp inclusion and switching off of consciousness, and its damage correlated with the duration of loss of consciousness). One of the authors of the work in question previously assumed that claustrum works as a conductor in an orchestra, combining all internal and external sensations into a complex perception. If so, these giant neurons can be considered proof of the role that claustrum plays in the mind. The researchers plan to continue marking the neurons coming from the claustrum to see if they all extend to the entire brain, or in different areas they are different. And, although it was very interesting to find neurons that may serve as a powerful switch for conscious behavior, it is worth keeping horses and not producing sensations like “FOUNDATION OF CONSCIOUSNESS OF CONDENSATION !! 1”. It will take a long time before these discoveries can be transferred to people, and decipher the mechanism behind such a miracle as our consciousness.

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Giant neurons. Blue – the largest of them

To less existential news. It is found out what exactly are the good comedians from your drunken uncle telling anecdotes about the Chukchi (and me writing this post). Researchers compared experienced comedians-improvizers with beginners to see where the brain contains creativity associated with humor. To do this, the researchers scanned the subjects, while they came up with funny labels for the caricatures of New Yorker. It was found that two parts of the brain are active in this process: the median prefrontal cortex (SPK) and the regions of temporal associative memory. But the level of their activation depended on the experience of the comedian. Experienced jokers have much more actively activated the area of ​​associative memory, participating in the work of memory, semantic knowledge, combining information into complex contextual associations and recognizing the language and visible objects. The newcomers relied more on the SEC, the area responsible for decision-making and planning. It seemed that the experience allows jokers to let go of control and allow free and spontaneous associations to behave, instead of trying to force a joke. The rating of jokes was also higher, the more the memory area was activated. Tried to come up with the final joke, but my temporary associative memory let me down.

And finally, futuristic news. Scientists managed to grow a brain from the dumped skin! Nearly. In fact, they turned skin cells into neural stem cells, from which neurons could grow. And, unlike previous similar experiments, all this was done without genetic manipulation. And this is important because it means that this technology can help fight neurodegenerative diseases (such as “we take a little skin and replace all the dead cells because of Parkinson’s cells”), and that we can now study genetic diseases of the nervous system in vitro – skin cells , Turning into neurons, will carry the same genetic mutation that leads to the disease, therefore, it is not necessary to take real neurons from the person.

MVB Staff
MVB Staff

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